Artichoke Spinach Grilled Cheese

Featured in: Everyday Mains

This decadent grilled cheese combines creamy spinach-artichoke dip with a melted blend of mozzarella, Monterey Jack, and Parmesan cheese between slices of golden sourdough bread. The filling features fresh spinach, artichoke hearts, softened cream cheese, and garlic, seasoned with black pepper and optional red pepper flakes. Simply assemble the sandwiches, butter the outside, and cook in a skillet over medium heat for 3-4 minutes per side until the bread turns golden brown and the cheese melts completely. Each sandwich is rich and satisfying, perfect served warm alongside tomato soup or a fresh salad. The filling can be prepared up to two days ahead for convenience.

Updated on Tue, 20 Jan 2026 08:26:00 GMT
Golden, crispy sourdough slices bursting with creamy spinach and artichoke filling for an indulgent Artichoke Spinach Grilled Cheese.  Save
Golden, crispy sourdough slices bursting with creamy spinach and artichoke filling for an indulgent Artichoke Spinach Grilled Cheese. | pulsebaker.com

The first time I made this, my roommate walked into the kitchen asking what restaurant I had ordered from. The smell of garlic and melting cheese had filled our entire tiny apartment, and honestly, I was pretty impressed with myself too. It was one of those Tuesday nights when cooking dinner felt like too much effort, but the craving for something warm and indulgent won out.

I made these for my book club last winter, and we ended up sitting around the table longer than usual, just talking and dipping our sandwich halves into tomato soup. Something about hot cheese and good conversation makes everything better. One friend admitted she usually hates artichokes but ended up asking for the recipe before she even left.

Ingredients

  • Fresh spinach: Adds color and nutrients, though frozen works perfectly fine if you thaw and drain it really well
  • Artichoke hearts: Canned or jarred work great, just make sure to chop them into small pieces so they distribute evenly
  • Cream cheese: softened to room temperature makes mixing so much easier
  • Mozzarella and Monterey Jack: This combo melts beautifully and creates that perfect cheese pull
  • Parmesan: Adds a salty, umami depth that balances the mild cheeses
  • Sourdough bread: Sturdy enough to hold the filling and gets incredibly crisp when grilled
  • Garlic: Fresh minced gives the best flavor punch
  • Red pepper flakes: Optional but adds just the right amount of warmth

Instructions

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Mix the filling:
Combine all the cheeses, spinach, artichokes, garlic, and seasonings in a bowl until its evenly blended. Taste and adjust salt if needed, though the Parmesan usually provides plenty.
Assemble the sandwiches:
Spread the cheesy mixture generously on four slices of bread, then top with the remaining slices. Press down gently so everything sticks together.
Butter the bread:
Spread softened butter on the outside of each sandwich. Do not skip this step, it is what creates that golden, restaurant style crunch.
Grill to perfection:
Cook in a hot skillet over medium heat for about 4 minutes per side. Press down lightly with your spatula so the bread makes good contact with the pan.
Rest and serve:
Let the sandwiches sit for a minute after cooking so the cheese sets slightly. Slice diagonally and watch everyone reach for a piece immediately.
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A close-up view of a perfectly melted Artichoke Spinach Grilled Cheese sandwich on a rustic wooden cutting board.  Save
A close-up view of a perfectly melted Artichoke Spinach Grilled Cheese sandwich on a rustic wooden cutting board. | pulsebaker.com

These have become my go to when friends come over for casual dinners. There is something universally appealing about grilled cheese, but the spinach and artichoke filling makes it feel special enough for company. Plus, everyone gets excited when they smell that buttery, garlicky goodness hitting the hot pan.

Make It Your Own

Sometimes I add sun dried tomatoes or chopped scallions to the filling for extra flavor. A little crispy bacon or prosciutto turns this into something entirely different if you want to move away from the vegetarian version. The base recipe is incredibly forgiving.

Bread Choices

Sourdough is my favorite because it holds up well and has a tangy flavor that cuts through all that cheese. Whole wheat adds nutrition and a nutty taste. Just avoid super soft bread that will get soggy under all that creamy filling.

Serving Ideas

These are substantial enough to be a meal on their own, especially with a simple side. The contrast between the hot, crispy sandwich and cool, creamy soup is pretty much perfect.

  • Tomato soup is the classic pairing for a reason
  • A light green salad with vinaigrette balances the richness
  • Pickles or fresh fruit cut through the heaviness
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Served hot and sliced diagonally, this vegetarian Artichoke Spinach Grilled Cheese is a decadent comfort food meal. Save
Served hot and sliced diagonally, this vegetarian Artichoke Spinach Grilled Cheese is a decadent comfort food meal. | pulsebaker.com

There is something so satisfying about cutting into a grilled cheese and seeing all that melted cheese stretch out. Hope these become a regular in your dinner rotation too.

Questions & Answers

Can I use frozen spinach instead of fresh?

Yes, absolutely. Use ½ cup frozen spinach, thawed and drained. Make sure to squeeze out excess moisture to prevent the filling from becoming watery.

What bread alternatives work best?

Whole wheat bread adds fiber and a nuttier flavor. Gluten-free bread works well for dietary needs. Ciabatta, focaccia, or thick-cut brioche are excellent alternatives to sourdough.

How do I prevent the cheese from leaking out?

Don't overstuff the sandwiches and spread the filling toward the edges. Use a spatula to gently press while cooking. Medium heat allows the cheese to melt without browning the bread too quickly.

Can I add other ingredients to the filling?

Definitely. Sun-dried tomatoes, caramelized onions, roasted red peppers, or fresh basil complement the spinach and artichoke filling beautifully.

What's the best way to store leftovers?

Store the filling separately in an airtight container for up to two days. Assemble and cook fresh when ready. The prepared filling works great for dipping with crackers or vegetables too.

Can I make this dairy-free?

Use dairy-free cream cheese, vegan mozzarella, and coconut oil instead of butter. Results vary by brand, so choose quality plant-based alternatives for best texture and flavor.

Artichoke Spinach Grilled Cheese

Golden sourdough sandwich filled with creamy spinach-artichoke mixture and melted cheese blend. A vegetarian comfort food favorite.

Prep Time
15 min
Time to Cook
10 min
Time Required
25 min
Created by Olivia Carter


Skill Level Easy

Cuisine American

Makes 4 Number of Servings

Diet Details Meat-Free

What You'll Need

Vegetables

01 1 cup fresh spinach, chopped (or 1/2 cup frozen, thawed and drained)
02 1 cup canned or jarred artichoke hearts, drained and chopped

Dairy

01 4 oz cream cheese, softened
02 1/2 cup shredded mozzarella cheese
03 1/2 cup shredded Monterey Jack or Swiss cheese
04 1/4 cup grated Parmesan cheese
05 2 tablespoons unsalted butter, softened

Bread

01 8 slices sourdough bread

Seasonings

01 1 small garlic clove, minced
02 1/4 teaspoon black pepper
03 1/8 teaspoon crushed red pepper flakes, optional
04 Pinch of salt

How To Make It

Step 01

Prepare the filling: In a mixing bowl, combine cream cheese, mozzarella, Monterey Jack or Swiss, Parmesan, spinach, artichokes, garlic, black pepper, red pepper flakes, and salt. Mix until well blended.

Step 02

Assemble sandwiches: Lay out sourdough slices and spread artichoke-spinach mixture evenly onto 4 slices. Top with remaining bread slices to form sandwiches.

Step 03

Butter the sandwiches: Lightly butter the outside of each sandwich on both sides.

Step 04

Cook until golden: Heat a large skillet or griddle over medium heat. Place sandwiches in the pan and cook 3-4 minutes per side, pressing gently, until bread is golden brown and cheese is melted.

Step 05

Rest and serve: Remove from skillet, let rest 1 minute, then slice and serve warm.

Tools You'll Need

  • Mixing bowl
  • Spoon or spatula
  • Knife and cutting board
  • Skillet or griddle
  • Spatula for flipping

Allergy Info

Look over the ingredients for possible allergens, and speak to a professional about concerns.
  • Contains dairy (cheese, butter) and wheat (bread)
  • May contain soy depending on bread and cheese brands
  • Check labels for potential cross-contamination if allergies are severe

Nutrition per Serving

Pulse Baker gives this for general use. It isn't medical guidance.
  • Calorie Count: 410
  • Fat content: 23 g
  • Carbohydrates: 38 g
  • Protein: 15 g