Italian Sub Grilled Cheese

Featured in: Everyday Mains

This Italian Sub Grilled Cheese brings together classic Italian cold cuts including salami and pepperoni with creamy provolone cheese and a tangy lettuce mixture featuring red wine vinegar and oregano. The sandwich is assembled on sturdy Italian bread, buttered on the outside, then griddled until the cheese melts and the bread turns golden brown.

Preparation takes just 20 minutes total, making it an ideal quick lunch or dinner option. The lettuce topping provides a fresh, zesty contrast to the rich meats and cheese, while optional pepperoncini adds extra flavor complexity. Serve hot, sliced in half, alongside your favorite sides.

Updated on Tue, 20 Jan 2026 13:32:00 GMT
Golden-brown Italian sub grilled cheese sandwich sliced on a cutting board, revealing layers of melted provolone, salami, and peppery lettuce.  Save
Golden-brown Italian sub grilled cheese sandwich sliced on a cutting board, revealing layers of melted provolone, salami, and peppery lettuce. | pulsebaker.com

The smell of salami and provolone hitting a hot skillet takes me back to late nights working at my uncles sub shop in Jersey. Something magical happens when those Italian cold cuts get warm and melty between buttery bread. This grilled cheese version captures that diner magic in twenty minutes flat.

My roommates used to request these on Friday nights when we were too broke to order out. Id stand at the stove, pressing down with my spatula while steam curled up from the pan. The first bite always made the whole week feel worth it.

Ingredients

  • 4 slices Italian bread: Sturdy bread holds up to the filling without getting soggy
  • 2 tablespoons unsalted butter: Softened butter spreads evenly for perfect golden crunch
  • 4 slices provolone cheese: Mild and melty, it binds everything together beautifully
  • 6 slices salami: Adds that classic Italian savory depth
  • 6 slices pepperoni: Brings a hint of heat and extra crisp when grilled
  • 1 cup shredded iceberg lettuce: Stays crisp and cool against the hot filling
  • 2 tablespoons mayonnaise: Creates the creamy base for the lettuce topping
  • 1 tablespoon red wine vinegar: Cuts through the rich meats and cheese
  • 1 teaspoon dried oregano: That signature sub shop flavor you cannot skip
  • Salt and pepper: Wake up all the other flavors

Instructions

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Make the lettuce topping:
Toss shredded lettuce with mayonnaise, red wine vinegar, oregano, salt, and pepper until evenly coated. Let it hang out while you prep everything else.
Prep your bread:
Butter one side of each bread slice generously. This is going to be the golden crispy exterior.
Layer it up:
Place two slices buttered side down and pile on provolone, salami, and pepperoni. Add any pepperoncini or onion you are feeling.
Add the crunch:
Spread that lettuce mixture right over the meats. It might seem weird but trust the process.
Close the deal:
Top with remaining bread slices, buttered side facing out. Press down gently to help everything settle.
Get that golden crust:
Cook in a hot skillet over medium heat for 3 to 4 minutes per side. Press gently with your spatula and watch for that perfect golden color.
Serve it up:
Cut each sandwich diagonally and serve while the cheese is still molten.
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Hearty Italian sub grilled cheese with crispy bread, melted provolone, and a colorful lettuce topping, served beside kettle chips.  Save
Hearty Italian sub grilled cheese with crispy bread, melted provolone, and a colorful lettuce topping, served beside kettle chips. | pulsebaker.com

These sandwiches became my go to for feeding hungry friends after long days. Watching people take that first bite, eyes widening at the hot cold contrast, never got old.

Bread Choices

Sourdough adds a nice tang that complements the Italian meats. Just make sure whatever you choose is sturdy enough to handle all those fillings without falling apart.

Make It Spicy

Hot giardiniera instead of mild pepperoncini transforms this into a whole different beast. The vinegar and heat cut through the cheese even more beautifully.

Serving Suggestions

A handful of kettle chips on the side feels like the right move. A simple tomato salad with vinaigrette balances all the richness perfectly.

  • Keep extra napkins nearby because these get messy
  • Serve immediately, do not let them sit or the bread loses its crunch
  • A cold Italian soda or beer pairs perfectly
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Sizzling Italian sub grilled cheese in a skillet, golden crust with visible salami and provolone melting between bread slices. Save
Sizzling Italian sub grilled cheese in a skillet, golden crust with visible salami and provolone melting between bread slices. | pulsebaker.com

Somehow this simple sandwich manages to taste like a special occasion every single time.

Questions & Answers

Can I use different types of bread?

Yes, Italian bread and sturdy white sandwich bread are recommended, but whole wheat or sourdough work well as alternatives. Choose bread with enough structure to hold the fillings without falling apart during grilling.

How do I prevent the cheese from leaking out?

Build your sandwich in layers: bread, cheese first, then meats, then the lettuce mixture on top. This helps contain the cheese. Press gently while grilling rather than aggressively to keep everything in place.

What's the best way to get crispy, golden bread?

Use medium heat and cook 3-4 minutes per side. Buttering the outside of the bread before grilling is key. A skillet or grill pan works better than a flat griddle for even heat distribution and better browning.

Can I make this vegetarian?

You can omit the salami and pepperoni and add roasted red peppers, sun-dried tomatoes, or grilled vegetables instead. The provolone cheese, lettuce mixture, and bread will still create a delicious grilled sandwich.

How do I add more heat to this sandwich?

Increase the oregano, add hot giardiniera instead of mild pepperoncini, or include sliced hot peppers. You can also drizzle hot sauce on the lettuce mixture or use spicy mayonnaise for extra kick.

Italian Sub Grilled Cheese

Melty grilled sandwich combining Italian cold cuts, provolone cheese, and tangy lettuce topping grilled to golden perfection.

Prep Time
10 min
Time to Cook
10 min
Time Required
20 min
Created by Olivia Carter


Skill Level Easy

Cuisine Italian-American

Makes 2 Number of Servings

Diet Details None specified

What You'll Need

Bread & Dairy

01 4 slices Italian bread or sturdy white sandwich bread
02 2 tablespoons unsalted butter, softened
03 4 slices provolone cheese

Meats

01 6 slices salami
02 6 slices pepperoni

Lettuce Topping

01 1 cup shredded iceberg lettuce
02 2 tablespoons mayonnaise
03 1 tablespoon red wine vinegar
04 1 teaspoon dried oregano
05 Salt and freshly ground black pepper to taste

Optional Additions

01 2 tablespoons mild pepperoncini rings, drained
02 2 tablespoons thinly sliced red onion

How To Make It

Step 01

Prepare Lettuce Mixture: In a mixing bowl, combine shredded iceberg lettuce, mayonnaise, red wine vinegar, dried oregano, salt, and freshly ground black pepper. Mix thoroughly and set aside.

Step 02

Butter Bread Slices: Lay out all bread slices and spread one side of each with softened unsalted butter.

Step 03

Layer Bottom Bread: Place two slices of buttered bread on a work surface with buttered side down. Top each slice with 2 slices of provolone cheese, 3 slices of salami, and 3 slices of pepperoni.

Step 04

Add Optional Toppings: If desired, distribute the optional pepperoncini rings and thinly sliced red onion evenly over the meats and cheese on both sandwich bases.

Step 05

Distribute Lettuce Mixture: Spread the prepared lettuce mixture evenly over the meats and cheese layer on each sandwich base.

Step 06

Top Sandwiches: Place the remaining bread slices on top of each sandwich with the buttered side facing upward.

Step 07

Grill Sandwiches: Heat a large skillet or grill pan over medium heat. Place sandwiches in the pan and cook for 3 to 4 minutes per side, pressing gently with a spatula, until the bread is golden brown and the cheese is fully melted.

Step 08

Finish and Serve: Remove sandwiches from heat, slice each in half diagonally, and serve hot.

Tools You'll Need

  • Skillet or grill pan
  • Spatula
  • Mixing bowl
  • Knife and cutting board

Allergy Info

Look over the ingredients for possible allergens, and speak to a professional about concerns.
  • Contains wheat from bread
  • Contains milk from cheese, butter, and mayonnaise
  • Contains eggs from mayonnaise; verify specific brand formulations
  • Contains pork from salami and pepperoni
  • Check all ingredient labels for potential trace allergens

Nutrition per Serving

Pulse Baker gives this for general use. It isn't medical guidance.
  • Calorie Count: 540
  • Fat content: 34 g
  • Carbohydrates: 35 g
  • Protein: 24 g